The United States has conducted a series of "freedom of navigation" exercises in the contested South China Sea, angering Beijing, which says the moves threaten its sovereignty.
"The South China Sea doesn`t belong to any one nation, and you can be sure: The United States will continue to sail and fly wherever international law allows and our national interests demand," Pence said.
China, Brunei, Malaysia, the Philippines, Vietnam and Taiwan, all have claims in the South China Sea, through which some $3 trillion of shipborne trade passes each year.
Pence on Thursday told leaders of Southeast Asian nations on there was no place for "empire and aggression" in the Indo-Pacific region, a comment that could be interpreted as a reference to China`s rise.
Pence`s latest comments follow a major speech in October in which he flagged a tougher approach by Washington towards Beijing, accusing China of "malign" efforts to undermine U.S.
President Donald Trump and reckless military actions in the South China Sea.
(Reporting by John Geddie
writing by Jack Kim; Editing by Michael Perry)