"Six people are dead," Nangarhar provincial police spokesman Hazrat Mohammad told AFP. NATO troops sealed off the area, Nangarhar provincial spokesman Ahmad Zia Abdul Zai told AFP.
There were no reports of NATO casualties in the attack, a spokesman for the International Security Assistance Force said.
"According to initial information the ISAF installation was not reached by the explosion," he said.
The Taliban, who are waging a 10-year insurgency against the Western-backed government of President Hamid Karzai, claimed responsibility for the blast.
The attack comes after at least 30 people were killed in six days of violent anti-US demonstrations across the country in protest over the burning of Korans at a US military airbase.
On Sunday, seven US soldiers were wounded in a grenade attack on their base in northern Kunduz province, police said.
President Hamid Karzai went on television Sunday to appeal for calm.
Karzai "condemned with the strongest words" the treatment of Islam`s holy book and said the perpetrators should be punished, but told his countrymen: "Now that we have shown our feelings it is time to be calm and peaceful."
He said he respected the emotions of Afghans upset by the Koran burning in an incinerator pit at Bagram base north of Kabul, but urged them not to let "the enemies of Afghanistan misuse their feelings".
Taliban insurgents have called on Afghans to kill foreign troops in revenge for the incident, and claimed to have been behind the shooting deaths of the two US advisers in the interior ministry in Kabul on Saturday.(*)
Editor: Heru Purwanto
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