The three were members of Hamas` Ezzedine al-Qassam Brigades, who were killed overnight Friday near the southern Gaza town of Khan Yunis, a statement said.
Hamas identified the three as Ismael Lubbad, Abdallah Lubbad and Mohammed Eldayah.
The strike is a "serious escalation" and Israel "will bear all the consequences", the Brigades warned.
Medical staff and witnesses earlier said that one person was also wounded in the air strike.
They said the target was a car driving between Khan Yunis and the Deir al-Balah refugee camp.
An Israeli military spokesman said the raid, planned jointly with the Shin Bet domestic security agency, was a preemptive strike against guerrillas planning to kidnap Israelis during the coming Jewish festival of Passover.
(U.C003)
Editor: Priyambodo RH
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