"Iran has always stressed cooperation with the IAEA and has done its utmost for transparency and removing the ambiguities" on the nuclear issue, Afkham told reporters in her weekly press briefing.
Also, under the new administration, Iran is pursuing a "new approach" in its interaction and cooperation with the IAEA, said the spokeswoman.
"Iran hopes the new approach facilitates Iran and the IAEA`s cooperation," she said, adding that the approach is expected to " answer (the IAEA`s) questions, remove the ambiguities, and lead to further cooperation."
The nuclear agency and Iran continued talks for a second day on Tuesday on Tehran`s disputed nuclear program.
The talks centering an inspection framework document began on Monday afternoon after the meeting between Iranian Deputy Foreign Minister Abbas Araqchi and the agency`s Chief Yukiya Amano.
Last week, Head of Atomic Energy Organization of Iran (AEOI) Ali-Akbar Salehi said his country was prepared to voluntarily cooperate with the IAEA over the "outstanding issues" and "the issues raised about possible military dimension to its nuclear program, although the matter is outside the purview of the UN agency."
On Sept. 27, Iran expressed its willingness to reach an agreement with the IAEA on nuclear inspection after their talks in Vienna.
The IAEA has held 12 rounds of meetings with Iran since 2011 without making any progress in the inspection framework.
One of the IAEA`s concerns is that Iran`s Parchin military site is capable of nuclear weapon-grade experiments. Iran has previously refused to grant access to the site unless an agreement has been reached on a "structured approach."
Iran is suspected by the IAEA of conducting possible experiments on developing nuclear weapons, which is firmly denied by Tehran.