Twain, 52, will release her first studio album in 15 years this week after a long struggle with Lyme disease and a devastating divorce.
"The album is really about a place that Ive come to, and Ive been for longer than Id like in a transition period," Twain said in an interview.
"Im just so relieved that Im finally here now on the other side of that ... so I thought it was really fitting to call the album Now as this is where Ive landed."
With hit songs like "Man! I Feel Like a Woman!" and the romantic "Youre Still the One," Twain won four Grammys for her 1997 best-selling album "Come on Over."
But in 2004, her vocal chords were damaged by Lyme disease, which also afflicts people with lethargy and joint pains. Four years later she split with her husband and musical partner Robert Lange, alleging he had cheated on her with her best friend.
Twain said she has worked hard to overcome the vocal damage.
"Theres a lot I can do about regaining my vocal competency, my vocal ability and Ive gone through all of that, so Im really grateful about that," she said. "But Ill never be able to remove the problem. Its a permanent injury."
Although Twain spent two years doing a nightly show in Las Vegas from 2012-2014 and toured North America in 2015, "Now" is her first album of new music since "Up!" in 2002. It goes on sale on Friday.
Twain is also filming a race car movie with John Travolta that is due for release in 2018.
"This has all just come out of just a phase that was a transition for me. So hey! Im feeling good," she said.