"We have agreed on granting asylum on Saadi Kadhafi for humanitarian reasons," Issoufou told a news conference at the end of a two-day visit to South Africa.
"Seif al-Islam is not in Niger. I would have to consider what to do if he comes," he said.
"We will deal with issues in terms of law and democracy and international agreements."
Saadi Kadhafi, 38, fled Libya across its southern frontier to Niger in August during the fall of Tripoli that ended his authoritarian father`s 42-year regime.
Libya`s new leadership wants Saadi Kadhafi to stand trial for crimes allegedly committed while heading the country`s football federation.
Niger`s Prime Minister Brigi Rafini said in September that there was "no question" of extraditing Saadi, at least until he could be assured of a fair trial in Libya.
Seif al-Islam, who is wanted by the International Criminal Court in relation to crimes against humanity allegedly committed during the crackdown against Libyan protests. (*)
Editor: Kunto Wibisono
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